7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine → HCID 86734826, compound

HRID 436794Notes

Reaction equation

HRID 436794 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1.CS([O:25][CH2:26][C:27](=O)[CH2:28][CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])(=O)=O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:27]([CH2:28][CH2:29][CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH2:26][OH:25])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:6]=2[CH:20]=1

Participants

4

Reactant 2

HCID 123908747-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepineHCID 21431482HCID 21431482, compound

Product 1

HCID 86734826HCID 86734826, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 5-carbomethoxy-2-oxopentyl methanesulfonate under nitrogen to give 7-chloro-2-[[2-hydroxy-1-(3-carbomethoxypropyl)ethylidene]hydrazino] -5-phenyl-3H-1,4-benzodiazepine, methanesulfonate ester.

Sources & evidence

ORD record
ord-a00466b43a8949c28aaf8691ab6cd2f3
Source dataset
uspto-grants-1977_06
Patent number
US04028356

Reaction notes

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