7-chloro-2-hydrazino-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine → HCID 53868323, compound

HRID 436797Notes

Reaction equation

HRID 436797 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[C:6]=2[CH:22]=1.[Cl:23][CH2:24][C:25](=O)[CH2:26][CH2:27][CH2:28][CH2:29][OH:30]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:25]([CH2:26][CH2:27][CH2:28][CH2:29][OH:30])[CH2:24][Cl:23])[CH2:9][N:8]=[C:7]([C:14]3[C:15]([F:21])=[CH:16][CH:17]=[CH:18][C:19]=3[F:20])[C:6]=2[CH:22]=1

Participants

4

Reactant 2

HCID 202918237-chloro-2-hydrazino-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepineHCID 20824368HCID 20824368, compound

Product 1

HCID 53868323HCID 53868323, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, 7-chloro-2-hydrazino-5-(2,6-difluorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1-chloro-6-hydroxy-2-hexanone under nitrogen to give 7-chloro-2-[[2-chloro-1-(4-hydroxybutyl)ethylidene]hydrazino]-5-(2,6-difluoropheny1)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-1822dd97edd44829b462ade95631f5d0
Source dataset
uspto-grants-1977_06
Patent number
US04028356

Reaction notes

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