反应详情

The same operation as in Example (91d) was performed using ethyl cis(±)-2-(3-butoxy-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate obtained in Example (120a) (0.34 g, 0.68 mmol), 2 N lithium hydroxide (5 mL, 10 mmol), methanol (3 mL) and THF (5 mL), to obtain 0.28 g of the title compound as a colorless solid (88%).