反应详情

In a process for the production of D,L-penicillamine by the reaction of isobutyraldehyde with sulfur and ammonia to form 2-isopropyl-5,5-dimethylthiazoline-3, conversion of the thiazoline with anhydrous hydrogen cyanide into 2-isopropyl-5,5-dimethylthiazolidine-4-carbonitrile, hydrolysis of the nitrile with hydrochloric acid to 2-isopropyl-5,5-dimethylthiazolidine-4-carboxylic acid hydrochloride and ammonium chloride, working up the mixture and separation of the ammonium chloride and hydrolytically breaking down the 2-isopropyl-5,5-dimethylthiazolidine-4-carboxylic acid to form penicillamine the improvement comprising carrying out the hydrolysis of the 2-isopropyl-5,5-dimethylthiazolidine-4-carbonitrile by (1) converting the 2-isopropyl-5,5-dimethylthiazolidine-4-carbonitrile with the hydrochloric acid into 2-isopropyl-5,5-dimethylthiazolidine-4-carbonamide hydrochloride at a temperature of 0° to 80° C and (2) converting the 2-isopropyl-5,5-dimethylthiazolidine-4-carbonamide hydrochloride into 2-isopropyl-5,5-dimethylthiazolidine-4-carboxylic acid hydrochloride at a temperature of 80° to 150° C.

1. customworking up the mixture and separation of the ammonium chloride