反应详情

To a stirred solution of methylhydrazine (0.07 mole) and triethylamine (0.06 mole) in dry tetrahydrofuran (100 ml) at 0° to 5° C. is added (1-ethoxycarbonyl)-ethylisocyanate (0.06 mole) over a period of 1 hour. The reaction mixture is allowed to warm to room temperature for 1 hour and filtered. The filtrate is evaporated to dryness and the residue is recrystallized from ether to give pure 2-azaalanylalanine ethyl ester, m.p. 77° -79.5° C.

1. filtrationfiltered
2. customThe filtrate is evaporated to dryness
3. customthe residue is recrystallized from ether