Hydrochloric Acid → HCID 21430461, compound

HRID 437148Notes

Reaction equation

HRID 437148 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:12](=[O:15])(=[O:14])[NH2:13].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.Cl>O>[ClH:1].[CH3:11][C:9]1[C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]([S:12](=[O:15])(=[O:14])[NH2:13])=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]2)[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 21430488HCID 21430488, compound

Product 1

HCID 21430461HCID 21430461, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

125 g of 4-chloro-6-methyl-3-sulfamoylbenzoic acid (0.5 mole) were heated under reflux with 0.5 l of N-methylpiperazine for 6 hours. Subsequently the excess base was eliminated in vacuo, and the residue was dissolved in 1 l of water. After the solution had been acidified with concentrated hydrochloric acid, the final product precipitated in a crystalline form. After having stood at room temperature for 1 hour, it was suction-filtered and was dissolved and recrystallized from 50% ethanol, while activated charcoal was added.

Workup

  1. customthe final product precipitated in a crystalline form
  2. filtrationit was suction-filtered
  3. dissolutionwas dissolved
  4. customrecrystallized from 50% ethanol, while activated charcoal
  5. additionwas added

Sources & evidence

ORD record
ord-31358c06a9924a61b89f8463d0131dcb
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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