Hydrochloric Acid → HCID 70638561, compound

HRID 437149Notes

Reaction equation

HRID 437149 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11](=[O:15])(=[O:14])[NH:12][CH3:13].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.Cl>>[ClH:1].[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=2[S:11](=[O:15])(=[O:14])[NH:12][CH3:13])[CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 8513544-chloro-3-[(methylamino)sulfonyl]benzoic acid

Product 1

HCID 70638561HCID 70638561, compound

Procedure

250 Grams of 4-chloro-3-methylsulfamoylbenzoic acid (1.0 mole) were stirred with 0.3 l of N-methylpiperazine for 4 hours at 130° C. When the hot reaction solution was introduced into 2 l of 2N HCl, the final product precipitated immediately in a crystalline form. The crude product was purified by recrystallization from a 2:2:1 mixture of ethanol/water/dimethylformamide.

Workup

  1. customthe final product precipitated immediately in a crystalline form
  2. customThe crude product was purified by recrystallization from a 2:2:1 mixture of ethanol/water/dimethylformamide

Sources & evidence

ORD record
ord-e2ec513e7ac14c27bb9d0a0e8a36acd7
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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