Hydrochloric Acid → HCID 21430453, compound

HRID 437151Notes

Reaction equation

HRID 437151 reaction equation
[CH3:1][N:2]([CH2:16][C:17]1[O:18][CH:19]=[CH:20][CH:21]=1)[C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7](Cl)=[C:6]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:5]=1.[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.Cl>O>[CH3:1][N:2]([CH2:16][C:17]1[O:18][CH:19]=[CH:20][CH:21]=1)[C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([N:26]2[CH2:27][CH2:28][N:23]([CH3:22])[CH2:24][CH2:25]2)=[C:6]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 214304753-(Aminosulfonyl)-4-chloro-N-(2-furanylmethyl)-N-methylbenzamide

Product 1

HCID 21430453HCID 21430453, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

103 Grams of 4-chloro-3-sulfamoylbenzoic acid-N-methyl-2-furylmethylamide (0.3 mole) were heated under reflux with 0.3 l of N-methylpiperazine for 5 hours. After the reaction solution had been poured into 2 l of water, the pH value of the mixture was adjusted to 8.0 with 5N HCl. After standing at room temperature for 3 days, the separated yellow resin had crystallized. The reaction product was suction-filtered, washed thoroughly with water and was recrystallized from a mixture of methanol and water.

Workup

  1. customthe separated yellow resin had crystallized
  2. filtrationThe reaction product was suction-filtered
  3. washwashed thoroughly with water
  4. customwas recrystallized from a mixture of methanol and water

Sources & evidence

ORD record
ord-2872cd9935364855b6cfc8b1433cbab0
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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