Hydrochloric Acid → HCID 21430464, compound

HRID 437156Notes

Reaction equation

HRID 437156 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11](=[O:16])(=[O:15])[N:12]([CH3:14])[CH3:13].[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.Cl>O>[CH3:13][N:12]([CH3:14])[S:11]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:2]=1[N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)[C:6]([OH:8])=[O:7])(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 4837PiperazineHCID 85307959210-61-6

Product 1

HCID 21430464HCID 21430464, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

264 Grams of 4-chloro-3-dimethylsulfamoylbenzoic acid (1.0 mole) and 345 g of anhydrous piperazine were heated at 130° C., while stirring, for 1 hour. Subsequently the reaction mixture was dissolved in 2 l of water and the pH value was adjusted to 7 with 5N HCl. After having stood over night, the crystalline precipitate was suction-filtered, washed with water and tetrahydrofurane and recrystallized from water.

Workup

  1. waitAfter having stood over night
  2. filtrationthe crystalline precipitate was suction-filtered
  3. washwashed with water and tetrahydrofurane
  4. customrecrystallized from water

Sources & evidence

ORD record
ord-6c711e2ed9aa4d059527f452326f9c4c
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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