Diethylamine → HCID 21430460, compound

HRID 437159Notes

Reaction equation

HRID 437159 reaction equation
Cl.[CH3:2][N:3]([CH3:23])[S:4]([C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[N:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)[C:10](Cl)=[O:11])(=[O:6])=[O:5].[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25]>O1CCCC1>[CH2:24]([N:26]([CH2:27][CH3:28])[C:10](=[O:11])[C:9]1[CH:13]=[CH:14][C:15]([N:16]2[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]2)=[C:7]([S:4](=[O:6])(=[O:5])[N:3]([CH3:23])[CH3:2])[CH:8]=1)[CH3:25]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 21430472HCID 21430472, compound

Product 1

HCID 21430460HCID 21430460, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

40 Grams of 3-dimethylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoylchloride-hydrochloride (0.1 mole) were introduced portionwise, while stirring at room temperature, into a solution of 20 g of diethylamine in 0.4 l of tetrahydrofurane. After the addition had been completed, the mixture was stirred for another 30 minutes at room temperature, and subsequently the tetrahydrofurane was completely eliminated in vacuo. The evaporation residue crystallized when triturated with 0.2 l of water, and, after having been suction-filtered and dried, it was recrystallized from butylacetate.

Workup

  1. additionAfter the addition
  2. customThe evaporation residue crystallized when
  3. customtriturated with 0.2 l of water
  4. filtrationafter having been suction-filtered
  5. customdried
  6. customit was recrystallized from butylacetate

Sources & evidence

ORD record
ord-767862a1fd66440899658cd32cc46cd4
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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