Water → HCID 21430447, compound

HRID 437175Notes

Reaction equation

HRID 437175 reaction equation
[CH3:1][N:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7](Cl)=[C:6]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:5]=1.[CH3:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.O>C(O)(=O)C>[CH3:1][N:2]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([N:27]2[CH2:28][CH2:29][N:24]([CH3:23])[CH2:25][CH2:26]2)=[C:6]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:5]=1

Participants

5

Reactant 3

HCID 962WaterHCID 531671-MethylpiperazineHCID 214304563-(Aminosulfonyl)-4-chloro-N-methyl-N-(phenylmethyl)benzamide

Product 1

HCID 21430447HCID 21430447, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

33.8 Grams of 4-chloro-3-sulfamoylbenzoic acid-N-methylbenzylamide (0.1 mole) were heated with 80 ml of N-methylpiperazine for 4 hours under reflux. Subsequently the solution was introduced into 0.4 l of water, the pH value of the mixture was adjusted to 9.0 by means of glacial acetic acid, and the mixture was then allowed to stand for 2 days at room temperature. The crystalline precipitate was separated and was recrystallized from a mixture of ethanol and water.

Workup

  1. temperatureunder reflux
  2. customThe crystalline precipitate was separated
  3. customwas recrystallized from a mixture of ethanol and water

Sources & evidence

ORD record
ord-1bf4827eb3854977b6883316797887c1
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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