反应详情

4-(1-Methylethyl)phenol (27.2 g., 0.20 moles) is dissolved in acetic acid (100 ml.). Iodine monochloride (32.5 g., 0.20 mole) in acetic acid (50 ml.) is then added slowly. The dark mixture is refluxed for 6 hours, cooled and poured into cold water (1 l.) containing a little sodium bisulfite. The black oil that separates is extracted with ether and the extract is washed with water and saturated brine and dried over magnesium sulfate. The ether is evaporated and the residue is purified by distillation to obtain 2-iodo-4-(1-methylethyl)phenol (26 g.), b.p. 137°-140° C. (15 mm.).

1. temperatureThe dark mixture is refluxed for 6 hours
2. temperaturecooled
3. extractionThe black oil that separates is extracted with ether
4. washthe extract is washed with water and saturated brine
5. dry with materialdried over magnesium sulfate
6. customThe ether is evaporated
7. distillationthe residue is purified by distillation