Hydrochloric Acid → 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(2-chlorobenzamido)-piperidine

HRID 437215Notes

Reaction equation

HRID 437215 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21](=[O:28])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:16][CH2:15]2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:28])[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=3[Cl:1])[CH2:18][CH2:19]2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21413257N-{1-[2-(3,4-dimethoxyphenyl)ethyl]-4-piperidinyl}benzamide

Product 1

HCID 214306161-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(2-chlorobenzamido)-piperidine

Procedure

The title compound as its hydrochloride (m.p. 250°-2° C.) was prepared in the same way as for the compound of Example 5 but using o-chlorobenzoyl chloride in place of benzoyl chloride. (Found: C, 60.2; H, 6.1; N, 6.3. C22H26Cl N2O3.HCl requires C, 60.3; H, 6.2; N, 6.4%).

Sources & evidence

ORD record
ord-96fdf89f768941adb6621716c504411f
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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