Potassium Carbonate → HCID 21430607, compound

HRID 437221Notes

Reaction equation

HRID 437221 reaction equation
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]=1.[C:13]([NH:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C>[CH2:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][N:25]2[CH2:26][CH2:27][CH:22]([NH:21][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:23][CH2:24]2)=[CH:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 121780961-bromo-2-(3-indenyl)ethane

Product 1

HCID 21430607HCID 21430607, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

3-(2-Bromoethyl)indene (1.12 g.), 4-benzamidopiperidine (1.02 g.) and potassium carbonate (1.38 g.) were heated under reflux in isopropanol (25 ml.) for 24 hours. The mixture was filtered and the filtrate was evaporated. Trituration of the residue with ether gave a solid which was recrystallised twice from aqueous ethanol to provide the title compound, m.p. 148°-149° C. (Found: C, 79.7; H, 7.6; N, 8.0. C23H26N2O requires C, 79.7; H, 7.6; N, 8.1%).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customTrituration of the residue with ether gave a solid which
  4. customwas recrystallised twice from aqueous ethanol

Sources & evidence

ORD record
ord-47494834c1144272b3ab85191e977b1c
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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