Isopropanol → HCID 15135602, compound

HRID 437238Notes

Reaction equation

HRID 437238 reaction equation
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16](=[O:19])([O-])[O-].[K+].[K+].[CH:22](O)([CH3:24])[CH3:23]>>[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:23][CH2:22][C:24]2[CH:6]=[CH:7][C:2]([O:19][CH3:16])=[CH:3][CH:4]=2)[CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 3776IsopropanolHCID 11430Potassium CarbonateHCID 118120N-4-Piperidylbenzamide

Product 1

HCID 15135602HCID 15135602, compound

Procedure

2-(p-Methoxyphenyl)ethanol p-toluenesulphonate ester (1.53 g.), 4-benzamidopiperidine (1.02 g.) and anhydrous potassium carbonate (1.10 g.) were refluxed in isopropanol (50 ml.) for 8 hours and the mixture worked up as in Example 48 to provide the title compound, which was further recrystallized from ethyl acetate as colourless needles (0.78 g.), m.p. 178° C. (Found: C, 74.7; H, 7.9; N, 8.45. C21H26N2O2 requires C, 74.5; H, 7.7; N, 8.3%).

Sources & evidence

ORD record
ord-b9140570d012456e860e8ed1a61a0718
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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