Hydrochloric Acid → HCID 21430623, compound

HRID 437242Notes

Reaction equation

HRID 437242 reaction equation
Cl.[C:2]1([O:12][CH2:13][CH2:14][CH2:15]Br)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[C:17]([NH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>>[C:2]1([O:12][CH2:13][CH2:14][CH2:15][N:29]2[CH2:30][CH2:31][CH:26]([NH:25][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:27][CH2:28]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 129593811-(3-Bromopropoxy)naphthalene

Product 1

HCID 21430623HCID 21430623, compound

Procedure

The title compound as its hydrochloride, m.p. 228° C. (decomp.), was prepared by the method of Example 52 using 3-naphthyloxypropyl bromide (2.07 g.), 4-benzamidopiperidine (1.8 g.) and anhydrous potassium carbonate (1.24 g.). (Found: C, 70.4; H, 7.0; N, 6.6. C25H28N2O2HCl requires C, 70.65; H, 6.9; N, 6.6%).

Sources & evidence

ORD record
ord-82a60c245eeb45d98f4a0fb1bee12a71
Source dataset
uspto-grants-1977_06
Patent number
US04029801

Reaction notes

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