Trifluoroacetic acid → HCID 70631663, compound

HRID 437328Notes

Reaction equation

HRID 437328 reaction equation
[CH3:1][O:2][C:3](=[O:41])[C@H:4]([CH2:37][CH:38]([CH3:40])[CH3:39])[NH:5][C:6](=[O:36])[C@@H:7]([CH3:35])[NH:8][C:9](=[O:34])[C@H:10]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:22][CH:21]=1)[NH:11]C(OC(C)(C)C)=O.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[CH3:1][O:2][C:3](=[O:41])[C@H:4]([CH2:37][CH:38]([CH3:40])[CH3:39])[NH:5][C:6](=[O:36])[C@@H:7]([CH3:35])[NH:8][C:9](=[O:34])[C@H:10]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:22][CH:21]=1)[NH2:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53689027HCID 53689027, compound

Product 1

HCID 70631663HCID 70631663, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Nα-t-butoxycarbonyl-O-benzyl-L-tyrosyl-D-alanyl-L-leucine methyl ester, 5.7 g., 10 mmol, in 20 ml. of dichloromethane and 50 ml. of trifluoroacetic acid are reacted together for 10 minutes at 25° C. The solution is evaporated and the residual oil used directly.

Workup

  1. customThe solution is evaporated

Sources & evidence

ORD record
ord-458421fea29441b3b99de0ad0366b0c6
Source dataset
uspto-grants-1977_06
Patent number
US04031071

Reaction notes

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