Hydrochloric Acid → HCID 12535843, compound

HRID 437443Notes

Reaction equation

HRID 437443 reaction equation
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([O:19]CC)=[O:18].[OH-].[Na+].Cl>>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12535800HCID 12535800, compound

Product 1

HCID 12535843HCID 12535843, compoundYield 100.2%

Procedure

A solution of ethyl 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxylate (2 g., 6.9 mmole) in 1N NaOH (20 ml., 20 mmole) was heated at reflux for 10 minutes. The solution was cooled and acidified with 6N HCl to yield the title product (1.8 g., m.p. 168°-184°). Recrystallization from acetonitrile gave 1.2 g. of colorless crystals, m.p. 186°-188°.

Workup

  1. temperatureat reflux for 10 minutes
  2. temperatureThe solution was cooled

Sources & evidence

ORD record
ord-ce4c3b87b1b94626854d964a88691da3
Source dataset
uspto-grants-1977_06
Patent number
US04031093

Reaction notes

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