Hydrochloric Acid → HCID 12535845, compound

HRID 437445Notes

Reaction equation

HRID 437445 reaction equation
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH:15]([CH3:17])[CH3:16])=[N:5][CH:4]=[C:3]1[C:18]([O:20]CC)=[O:19].Cl>[OH-].[Na+]>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH:15]([CH3:17])[CH3:16])=[N:5][CH:4]=[C:3]1[C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12535802HCID 12535802, compound

Product 1

HCID 12535845HCID 12535845, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of ethyl 1,6-dihydro-6-oxo-2-(2-isopropoxyphenyl)pyrimidine-5-carboxylate (3.02 g.) in 1N NaOH (25 ml.) was heated on a steam bath for 15 minutes. The solution was acidified with 1N HCl (26 ml.) to precipitate 2.7 g. of the title acid, m.p. 191°-193°. Recrystallization from methanol gave pale yellow crystals of the acid, m.p. 193°-195°.

Workup

  1. customto precipitate 2.7 g
  2. customRecrystallization from methanol
  3. customgave pale yellow crystals of the acid, m.p. 193°-195°

Sources & evidence

ORD record
ord-3ffce8a1b5714b87a91d0a115d57334c
Source dataset
uspto-grants-1977_06
Patent number
US04031093

Reaction notes

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