Phenyl Isothiocyanate → 1-[4-(2-Formylhydrazinyl)-3-methoxyphenyl]-3-phenylthiourea

HRID 437516Notes

Reaction equation

[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[O:12][CH3:13])=[O:2].[C:14]1([N:20]=[C:21]=[S:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:21]([NH:20][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[S:22])=[CH:7][C:6]=1[O:12][CH3:13])=[O:2]

Participants

Reactant 2

HCID 7673Phenyl Isothiocyanate

HCID 214278421-Formyl-2-(4-amino-2-methoxyphenyl)hydrazine

Product 1

HCID 214278241-[4-(2-Formylhydrazinyl)-3-methoxyphenyl]-3-phenylthiourea

Procedure

Procedure (18.) was employed with 1-formyl-2-(4-amino-2-methoxyphenyl)hydrazine (1.0 g, 0.0056 mole) and phenyl isothiocyanate (0.75 g, 0.0056 mole). Yield 0.90 g (51%), m.p. 183°-184° C.

Sources & evidence

ORD record: ord-6efd904eef3b49aea3c18a457d7bdf3d
Source dataset: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04031127

Reaction notes

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