反应详情

1-(4-Chlorobenzoyl)-2-(4-aminophenyl)hydrazine hydrochloride (1.5 g, 0.005 mole) was dissolved in hot ethanol (30 ml) under a nitrogen atmosphere. Benzyl isothiocyanate (0.82 g, 0.0055 mole) and potassium acetate (0.6 g, 0.006 mole) were added and the mixture was refluxed under nitrogen for 2 hours. The reaction mixture was cooled to room temperature, diluted with water (10-15 ml.) and chilled in ice. The product was filtered off, washed with ethanol and dried. Recrystallization of the product from acetonitrile gave an off-white solid. Yield 1.25 g (62%), m.p. 197°-199° C.

1. temperaturethe mixture was refluxed under nitrogen for 2 hours
2. temperaturechilled in ice
3. filtrationThe product was filtered off
4. washwashed with ethanol
5. customdried
6. customRecrystallization of the product from acetonitrile
7. customgave an off-white solid