Aluminium lithium hydride → HCID 21428707, compound

HRID 437571Notes

Reaction equation

HRID 437571 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][C:8]1[NH:9][C:10]2[C:15]([C:16]=1[C:17](=O)[C:18]([N:20]1[CH2:25][CH2:24][CH:23]([O:26][C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=3)[CH2:22][CH2:21]1)=O)=[CH:14][CH:13]=[CH:12][CH:11]=2>O1CCCC1>[F:33][C:30]1[CH:29]=[CH:28][C:27]([O:26][CH:23]2[CH2:22][CH2:21][N:20]([CH2:18][CH2:17][C:16]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[NH:9][C:8]=3[CH3:7])[CH2:25][CH2:24]2)=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21428708HCID 21428708, compound

Product 1

HCID 21428707HCID 21428707, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

By following the manipulative procedure described in Example 2(d), 5.5 g of lithium aluminum hydride in 160 ml. of tetrahydrofuran and 12.0 g of 1-(2-methylindol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine in 120 ml. of tetrahydrofuran are reacted to produce a white solid. The solid is recrystallized from an ethanol and water mixture (charcoal treatment) to give a white powder of 3-{2-[4-(p-fluorophenoxy)piperidyl]ethyl}-2-methylindole, m.p. 97°-99° C.

Workup

  1. customto produce a white solid
  2. customThe solid is recrystallized from an ethanol and water mixture (charcoal treatment)

Sources & evidence

ORD record
ord-79f28b43154e491094602553fb516c87
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Reaction notes

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