Aluminium lithium hydride → HCID 21428701, compound

HRID 437572Notes

Reaction equation

HRID 437572 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]1[CH:35]=[CH:34][C:11]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19](=O)[C:20]([C:22]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=4)[NH:24][CH:23]=3)=O)[CH2:15][CH2:14]2)=[CH:10][CH:9]=1>O1CCCC1>[F:7][C:8]1[CH:9]=[CH:10][C:11]([O:12][CH:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][C:22]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([O:31][CH3:32])[CH:29]=4)[NH:24][CH:23]=3)[CH2:17][CH2:18]2)=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21428696HCID 21428696, compound

Product 1

HCID 21428701HCID 21428701, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

By following the manipulative procedure described in Example 2(d), 8.0 g of lithium aluminum hydride in 235 ml. of tetrahydrofuran and 18.0 g of 4-(p-fluorophenoxy)-1-(5-methoxyindol-3-ylglyoxyloyl)piperidine in 190 ml. of tetrahydrofuran are reacted to produce a white solid. The solid is recrystallized twice from 95% ethanol (charcoal treatment) to give white crystals of 3-{2-[4-(p-fluorophenoxy)piperidyl]ethyl}5-methoxyindole, m.p. 132°-134° C.

Workup

  1. customto produce a white solid
  2. customThe solid is recrystallized twice from 95% ethanol (charcoal treatment)

Sources & evidence

ORD record
ord-f76e9ebb85a24e4bb9373e2b770b5bbb
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Reaction notes

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