Aluminium lithium hydride → HCID 21428720, compound

HRID 437578Notes

Reaction equation

HRID 437578 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[NH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([C:16](=O)[C:17]([N:19]2[CH2:22][CH:21]([O:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)[CH2:20]2)=O)=[CH:8]1>O1CCCC1>[F:30][C:27]1[CH:26]=[CH:25][C:24]([O:23][CH:21]2[CH2:20][N:19]([CH2:17][CH2:16][C:9]3[C:10]4[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=4)[NH:7][CH:8]=3)[CH2:22]2)=[CH:29][CH:28]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 214287131-[3-(4-Fluorophenoxy)-1-azetidinyl]-2-(1H-indol-3-yl)-1,2-ethanedione

Product 1

HCID 21428720HCID 21428720, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

By following the manipulative procedure described in Example 2(d), 0.7 g of lithium aluminum hydride in 30 ml. of tetrahydrofuran and 1.5 g of 1-(indol-3-ylglyoxyloyl)-3-(p-fluorophenoxy)azetidine in 30 ml. of tetrahydrofuran are reacted to produce a white solid. The solid is recrystallized twice from an ethanol and water mixture to give colorless needles of 3-{2-[3-(p-fluorophenoxy)azetidinyl]ethyl}indole, m.p. 111°-113°.

Workup

  1. customto produce a white solid
  2. customThe solid is recrystallized twice from an ethanol and water mixture

Sources & evidence

ORD record
ord-37a4ef8798cc40d3bea58bc272f6ee54
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Reaction notes

Loading…