反应详情

温度

0 °C

To 231 parts of a aziridine solution 0.95M in water are added 16 parts of sodium hydrogen carbonate while stirring vigorously at 0° C. Then there is added dropwise, during a 45 minutes-period, a solution of 36 parts of 4-fluoro-2-methoxybenzoyl chloride in 150 parts of trichloromethane while still cooling at 0° C. Upon completion, stirring is continued for 30-45 minutes without cooling. The reaction mixture is adjusted to pH 8 with a diluted sodium hydroxide solution and the product is extracted three times with trichloromethane. The combined extracts are washed three times with water, dried, filtered and evaporated, yielding 40.5 parts of 1-(4-fluoro-2-methoxybenzoyl)-aziridine as a residue.

1. additionThen there is added dropwise, during a 45 minutes-period
2. stirringUpon completion, stirring
3. temperaturewithout cooling
4. extractionthe product is extracted three times with trichloromethane
5. washThe combined extracts are washed three times with water
6. customdried
7. filtrationfiltered
8. customevaporated