Aziridine → HCID 21428810, 화합물

HRID 437617노트

반응식

HRID 437617 반응식
[NH:1]1[CH2:3][CH2:2]1.C(=O)([O-])O.[Na+].[F:9][C:10]1[CH:18]=[CH:17][C:13]([C:14](Cl)=[O:15])=[C:12]([O:19][CH3:20])[CH:11]=1.[OH-].[Na+]>O.ClC(Cl)Cl>[F:9][C:10]1[CH:18]=[CH:17][C:13]([C:14]([N:1]2[CH2:3][CH2:2]2)=[O:15])=[C:12]([O:19][CH3:20])[CH:11]=1

참가 물질

7

반응물 4

HCID 9033AziridineHCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 133524094-Fluoro-2-methoxybenzoyl chloride

생성물 1

HCID 21428810HCID 21428810, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

To 231 parts of a aziridine solution 0.95M in water are added 16 parts of sodium hydrogen carbonate while stirring vigorously at 0° C. Then there is added dropwise, during a 45 minutes-period, a solution of 36 parts of 4-fluoro-2-methoxybenzoyl chloride in 150 parts of trichloromethane while still cooling at 0° C. Upon completion, stirring is continued for 30-45 minutes without cooling. The reaction mixture is adjusted to pH 8 with a diluted sodium hydroxide solution and the product is extracted three times with trichloromethane. The combined extracts are washed three times with water, dried, filtered and evaporated, yielding 40.5 parts of 1-(4-fluoro-2-methoxybenzoyl)-aziridine as a residue.

후처리

  1. additionThen there is added dropwise, during a 45 minutes-period
  2. stirringUpon completion, stirring
  3. temperaturewithout cooling
  4. extractionthe product is extracted three times with trichloromethane
  5. washThe combined extracts are washed three times with water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

출처 및 근거

ORD 기록
ord-054f5abc254d43959ea04fcb7d96981f
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031226

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