Methyl iodide → 1-Ethyl-2-phenyl-4-(trifluoromethyl)-1H-imidazole
Reaction equation
[CH2:1](I)[CH3:2].[C:4]1([C:10]2[NH:11][CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.CI.CN1C=C(C(F)(F)F)N=C1C1C=CC=CC=1>>[CH2:1]([N:11]1[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=[C:10]1[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)[CH3:2]Participants
5
Procedure
By substituting equivalent amounts of ethyl iodide and 2-phenyl-4-trifluoromethylimidazole for the methyl iodide and 2-(2-pyridyl)-4(5)-trifluoromethylimidazole of Example 57 and following substantially the procedure described therein there is obtained 1-ethyl-2-phenyl-4-trifluoromethylimidazole, b.p., 160°-165° C. at 0.5 mm.
Sources & evidence
- ORD record
- ord-b054b1e9d44d4f3690f5c50933d6deae
- Source dataset
- uspto-grants-1977_06
- Patent number
- US04032522
Reaction notes
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