Isopropanol → HCID 20371581, compound

HRID 437905Notes

Reaction equation

HRID 437905 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[CH2:7][CH2:8][NH:9][CH2:10][CH:11]([OH:26])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18]CC2C=CC=CC=2)[CH:13]=1.C(O)(C)C>[C].[Pd].O>[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:27]=[CH:28][C:29]=1[O:30][CH3:31])[CH2:7][CH2:8][NH:9][CH2:10][CH:11]([OH:26])[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=1

Participants

5

Reactant 2

HCID 3776IsopropanolHCID 20371582HCID 20371582, compound

Product 1

HCID 20371581HCID 20371581, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 962WaterSolvent

Procedure

2 g of α-(3,4-dimethoxyphenethylaminomethyl)-3-benzyloxybenzylalcohol hydrochloride, 0.5 g of 10 % palladium-carbon, 100 ml of isopropanol and 15 ml of water are treated in the same manner as described in Example 1-(c). 1.45 g of α-(3,4dimethoxyphenethylaminomethyl)-3-hydroxybenzylalcohol hydrochloride are obtained. M.p. 161° -162° C.(recrystallized from a mixture of isopropanol and ether).

Sources & evidence

ORD record
ord-c62f13db34d949398f5b65cea7c1c23a
Source dataset
uspto-grants-1977_06
Patent number
US04032575

Reaction notes

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