Hydrochloric Acid → HCID 178477851, compound

HRID 437936Notes

Reaction equation

HRID 437936 reaction equation
CO[C:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][N:4]=1.Cl.[NH2:11][CH:12]1[C:21]2[CH:20]=[CH:19][S:18][C:17]=2[CH2:16][CH2:15][C:14]2[CH:22]=[CH:23][C:24]([Cl:26])=[CH:25][C:13]1=2.Cl>CCOCC.C(O)C>[Cl:26][C:24]1[CH:23]=[CH:22][C:14]2[CH2:15][CH2:16][C:17]3[S:18][CH:19]=[CH:20][C:21]=3[CH:12]([N:11]=[C:3]3[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][NH:4]3)[C:13]=2[CH:25]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 756572H-Azepine, 3,4,5,6-tetrahydro-7-methoxy-HCID 214274174-amino-6-chloro-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene hydrochloride

Product 1

HCID 178477851HCID 178477851, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherCatalystHCID 702EthanolSolvent

Procedure

5 ml of 98% ethanol and 10.0 g of caprolactim 0-methyl ether are added to 8.0 g of 4-amino-6-chloro-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene hydrochloride and are allowed to stand at room temperature while shaking occasionally. A few drops of ether are added to the resulting clear solution after 12 hours, whereupon the hydrochloride of the title compound crystallizes. M.Pt. decomp. from 185°, (recrystallized once from ethanol/ether).

Workup

  1. customto stand at room temperature

Sources & evidence

ORD record
ord-c3df77681588463f9f6e45377778a906
Source dataset
uspto-grants-1977_06
Patent number
US04032640

Reaction notes

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