Hydrochloric Acid → HCID 22411254, compound

HRID 439317Notes

Reaction equation

HRID 439317 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([NH2:13])[C:11]=1[OH:12])[C:5]([O:7][CH3:8])=[O:6].[ClH:14]>CO>[ClH:14].[ClH:14].[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([NH2:13])[C:11]=1[OH:12])[C:5]([O:7][CH3:8])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22411216HCID 22411216, compound

Product 1

HCID 22411254HCID 22411254, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

The resultant ester was dissolved in minimum amount of methanol and cooled to 0° C. Dry hydrogen chloride gas was passed through the mixture for 15 minutes. After storing -20° C. overnight, the separated solid was filtered and dried. It was crystallized from ethanol, water and ether to give the desired compound 1.80 g (57%), m.p. 251-252.

Workup

  1. filtrationthe separated solid was filtered
  2. customdried
  3. customIt was crystallized from ethanol, water and ether

Sources & evidence

ORD record
ord-e1dbf669f1264511ad4cf8a0adc706d8
Source dataset
uspto-grants-1996_05
Patent number
US05514676

Reaction notes

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