Hydrochloric Acid → HCID 22411275, compound

HRID 439318Notes

Reaction equation

HRID 439318 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([NH2:15])[C:13]=1[OH:14])[C:5]([O:7][CH:8]([CH3:10])[CH3:9])=[O:6].[ClH:16]>CO>[ClH:16].[ClH:16].[NH2:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([NH2:15])[C:13]=1[OH:14])[C:5]([O:7][CH:8]([CH3:10])[CH3:9])=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22411158HCID 22411158, compound

Product 1

HCID 22411275HCID 22411275, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

The ester was dissolved in minimum amount of methanol and cooled to 0° C. Dry hydrogen chloride gas was passed through the mixture for 15 minutes. It was stored at -20 ° C. overnight, whereupon the solid which separated was filtered and dried. It was crystallized from ethanol, water and ether mixture to give 1.66 g of the title product (53%), m.p. 247°-249° C.

Workup

  1. customseparated
  2. filtrationwas filtered
  3. customdried
  4. customIt was crystallized from ethanol, water and ether mixture

Sources & evidence

ORD record
ord-909059aa8e7c4396b46a145ff92afdd8
Source dataset
uspto-grants-1996_05
Patent number
US05514676

Reaction notes

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