Hydrochloric Acid → HCID 67904766, compound

HRID 439343Notes

Reaction equation

HRID 439343 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:4]=[C:3]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:2]=1.[ClH:17]>C(O)(C)C>[ClH:17].[N:1]1[CH:2]=[C:3]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 78340Diethyl pyridine-3,5-dicarboxylate

Product 1

HCID 67904766HCID 67904766, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The compound 1,4-dihydro-2,6-dimethyl-4- 3-(1H-imidazol-1-yl)phenyl!-3,5-pyridinedicarboxylic acid, diethyl ester (0.1 g) was dissolved in isopropyl alcohol (2 ml) and treated with isopropanolic HCl. The solution was evaporated to dryness and the residue crystallized from ethylacetate/ethanol (3:1) mixture. The salt 1,4-dihydro-2,6-dimethyl-4- 3-(1H-imidazol-1-yl)phenyl!-3,5-pyridinedicarboxylic acid, diethyl ester hydrochloride was obtained in quantitative yield, m.p. 235°-240° C. (dec.).

Workup

  1. customThe solution was evaporated to dryness
  2. customthe residue crystallized from ethylacetate/ethanol (3:1) mixture

Sources & evidence

ORD record
ord-c8de70eab17e4cfabf5cf2e96018dbba
Source dataset
uspto-grants-1996_05
Patent number
US05514693

Reaction notes

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