反应详情

Adenine (9.1 g), ethylene carbonate (6.0 g), and sodium hydroxide (0.14 g) in DMF (68 ml) were heated at reflux for 2 hr The solution was cooled to 0°, then 70 ml of toluene were added. After sitting for 2 hr at 0°, the precipitate was collected, rinsed with 100 ml of toluene, then cold ethanol, and dried to afford N9 -hydroxyethyladenine.

1. temperatureat reflux for 2 hr The solution
2. temperaturewas cooled to 0°
3. customthe precipitate was collected
4. washrinsed with 100 ml of toluene
5. dry with materialcold ethanol, and dried