反应详情

To 14.7 gm of the Wittig salt prepared from 1-bromopentane and triphenylphosphine in 80 ml of tetrahydrofuran at 0° C. is added 22.5 ml of n-butyl lithium (1.6M) in hexane. The mixture is stirred for 15 minutes, and 3.8 ml of 3-bromobenzaldehyde is added. This mixture is stirred for 30 minutes; and after concentrating and diluting with ether, the solids are filtered off. Further concentration of the filtrate and chromatography over silica gel eluting with 3:2 hexane:ether yields pure 3-bromo-(1-hexenyl)benzene as a clear oil.

1. stirringThis mixture is stirred for 30 minutes
2. concentrationand after concentrating
3. additiondiluting with ether
4. filtrationthe solids are filtered off
5. concentrationFurther concentration of the filtrate and chromatography over silica gel eluting with 3:2 hexane