反应详情

A mixture of 3-amino-4-(4-benzylphenyl )-2-carbamoylpyrazole (1.00 g), ethyl orthoformate (0.61 ml) and N,N-dimethylformamide (0.86 ml) was stirred at 100° C. to 110° C. for 45 minutes. To the reaction mixture was added ethyl acetate (20 ml). After stirring at room temperature for 30 minutes, the precipitate was separated by filtration, washed with ethyl acetate, and dried to give the title compound (0.72 g).

1. stirringAfter stirring at room temperature for 30 minutes
2. customthe precipitate was separated by filtration
3. washwashed with ethyl acetate
4. customdried