Dimethylformamide → HCID 178517943, compound

HRID 439779Notes

Reaction equation

HRID 439779 reaction equation
[NH2:1][C:2]1[N:3]([C:20](=[O:22])[NH2:21])[N:4]=[CH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:9][CH:8]=1.[CH:23]([O-])([O-])OCC.CN(C)C=O>C(OCC)(=O)C>[CH2:13]([C:10]1[CH:9]=[CH:8][C:7]([C:6]2[CH:5]=[N:4][N:3]3[C:20]([OH:22])=[N:21][CH:23]=[N:1][C:2]=23)=[CH:12][CH:11]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 152804693-Amino-4-(4-benzylphenyl)-2-carbamoylpyrazoleHCID 53630039Ethylorthoformate

Product 1

HCID 178517943HCID 178517943, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-amino-4-(4-benzylphenyl )-2-carbamoylpyrazole (1.00 g), ethyl orthoformate (0.61 ml) and N,N-dimethylformamide (0.86 ml) was stirred at 100° C. to 110° C. for 45 minutes. To the reaction mixture was added ethyl acetate (20 ml). After stirring at room temperature for 30 minutes, the precipitate was separated by filtration, washed with ethyl acetate, and dried to give the title compound (0.72 g).

Workup

  1. stirringAfter stirring at room temperature for 30 minutes
  2. customthe precipitate was separated by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-eab8df1e14c44405a96faa46c70844b5
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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