Dimethylformamide → HCID 178424832, compound

HRID 439791Notes

Reaction equation

HRID 439791 reaction equation
[NH2:1][C:2]1[N:3]([C:21](=[O:23])[NH2:22])[N:4]=[CH:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=2)=[CH:9][CH:8]=1.[CH:24]([O-])([O-])OCC.CN(C)C=O>C(OCC)(=O)C>[OH:23][C:21]1[N:3]2[N:4]=[CH:5][C:6]([C:7]3[CH:12]=[CH:11][C:10]([CH2:13][C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=4)=[CH:9][CH:8]=3)=[C:2]2[N:1]=[CH:24][N:22]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 20076639HCID 20076639, compoundHCID 53630039Ethylorthoformate

Product 1

HCID 178424832HCID 178424832, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 3-amino-2-carbamoyl-4- {4-(3-methylphenylmethyl) phenyl} pyrazole (3.0 g), ethyl orthoformate (2 ml) and N,N-dimethylformamide (4 ml) was heated and stirred at 100° C. to 110° C. After 1 hour, to the mixture was added ethyl acetate (50 ml). The precipitate was separated by filtration, washed with etyl acetate, dried to give the title compound (2.0 g).

Workup

  1. temperaturewas heated
  2. customThe precipitate was separated by filtration
  3. washwashed with etyl acetate
  4. customdried

Sources & evidence

ORD record
ord-873b800633f144e488e2ee36dc150041
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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