Hydrochloric Acid → HCID 22408208, compound

HRID 439811Notes

Reaction equation

HRID 439811 reaction equation
C1O[CH:4]([C:5]2[CH:10]=[CH:9][C:8]([CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=3)=[CH:7][CH:6]=2)[O:3]C1.Cl.[Cl-].[Na+]>O1CCCC1>[CH3:19][O:18][C:14]1[CH:13]=[C:12]([CH2:11][C:8]2[CH:7]=[CH:6][C:5]([CH:4]=[O:3])=[CH:10][CH:9]=2)[CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 22408234HCID 22408234, compound

Product 1

HCID 22408208HCID 22408208, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4-(3-Methoxyphenylmethyl)benzaldehyde ethylene acetal (700 mg, 2.6 millimol) was dissolved in tetrahydrofuran (5 ml), and thereto was added 10% hydrochloric acid. After stirring at room temperature for 30 minutes, to the mixture was added saturated aqueous sodium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed, dried over anhydrous sodium sulfate, and the solvent was distilled away to give the title compound (580 mg, 2.6 millimol, 100%).

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe extract was washed
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationthe solvent was distilled away

Sources & evidence

ORD record
ord-3bddc7c2c208464198928e26bc9919dd
Source dataset
uspto-grants-1996_05
Patent number
US05516777

Reaction notes

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