Tetrabutylammonium Fluoride → HCID 178454090, compound

HRID 439888Notes

Reaction equation

HRID 439888 reaction equation
[C:1]([NH:8][C@H:9]1[CH2:12][C@H:11]([CH2:13][O:14][Si](C(C(C)C)(C)C)(C)C)[CH2:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[C:1]([NH:8][C@H:9]1[CH2:12][C@H:11]([CH2:13][OH:14])[CH2:10]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 178445577HCID 178445577, compound

Product 1

HCID 178454090HCID 178454090, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Analogously to Example 6b, starting from a solution of 13.2 g (0.03842 mol) of trans3-(N-BOC-amino)-1-(thexyl-dimethylsilyl)oxymethyl-cyclobutane (cf. Example 6c) in 60 ml of tetrahydrofuran and 76.8 ml (0.0768 mol) of a 1M tetrabutylammonium fluoride solution in tetrahydrofuran, the title compound is obtained, m.p. 98°-100° C.

Sources & evidence

ORD record
ord-23cbff4542244290931430315f79c071
Source dataset
uspto-grants-1996_05
Patent number
US05516806

Reaction notes

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