Potassium Carbonate → 1-(4-benzyloxy-2-nitrophenoxy)-2(2,3-Difluoro-6-nitrophenoxy) ethane

HRID 440129Notes

Reaction equation

[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-:11])=[O:10])[C:3]=1[OH:12].C([O-])([O-])=O.[K+].[K+].Br[CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:25][C:24]=1[N+:37]([O-:39])=[O:38]>CN(C=O)C.CCOCC>[CH2:30]([O:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][CH2:21][CH2:20][O:12][C:3]2[C:4]([N+:9]([O-:11])=[O:10])=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])=[C:24]([N+:37]([O-:39])=[O:38])[CH:25]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

Conditions

Temperature: 70 °C

Procedure

2,3-Difluoro-6-nitrophenol (0.7 g, 3.7 mmol) was stirred with K2CO3 (0.5 g, 3.7 mmol) in DMF (10 mL) for 10 min. Bromoethane 6 (1.1 g, 3.1 mmol) was added to the reaction mixture and heated at 70° C. for 24 hrs. The reaction mixture was diluted with ether (30 mL) and washed with water (20 mL) and then brine (20 mL). The ether layer was dried (MgSO4) and concentrated under reduced pressure. Fractionation of the crude product by flash chromatography with 4:1 hexane/ethyl acetate provided 7 as a yellow oil (960 mg, 63%). 1H NMR: 4.45 (t, J=5 Hz, 2H), 4.71 (t, J=5 Hz, 2H), 5.05 (s, 2H), 7.0-7.7 (m, 10H)

Workup

washwashed with water (20 mL)
dry with materialThe ether layer was dried (MgSO4)
concentrationconcentrated under reduced pressure

Sources & evidence

ORD record: ord-74ad91ec960d4992b1caafb0478ae4ed
Source dataset: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05516911

Reaction notes

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