反应详情

3.0 g (14.2 mmol) of 1-bromo-2,4,5-trifluorobenzene are refluxed under protecting gas with 30.0 mmol of 2-ethylhexyl acrylate, 140 mg of palladium on activated charcoal (5% strength), 0.82 g of sodium carbonate and 10 mg of di-tert-butylphenol in 10 ml of dimethylacetamide for 18 hours at 170° C. The catalyst is filtered off, the mixture is diluted with dichloromethane and extracted with water. The crude product is chromatographed.

1. customfor 18 hours
2. customat 170° C
3. filtrationThe catalyst is filtered off
4. additionthe mixture is diluted with dichloromethane
5. extractionextracted with water
6. customThe crude product is chromatographed