Sulfuric Acid → HCID 22077247, compound

HRID 440159Notes

Reaction equation

HRID 440159 reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[C:6]([F:10])=[CH:5][C:3]=1[NH2:4].[S:11](=[O:15])(=[O:14])([OH:13])[OH:12].[N:16](OCCCCC)=O>C(O)C>[S:11]([O-:15])([OH:14])(=[O:13])=[O:12].[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[C:6]([F:10])=[CH:5][C:3]=1[N+:4]#[N:16]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 10026Pentyl nitriteHCID 27580982,4-Dichloro-5-fluoroaniline

Product 1

HCID 22077247HCID 22077247, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

36.0 g (0.20 mol) of 2,4-dichloro-5-fluoroaniline are dissolved at room temperature in 180 ml of ethanol and 36.0 g of concentrated sulfuric acid are added with cooling. To this mixture are added dropwise 27.0 ml (0.23 mol) of amyl 1 nitrite. The diazonium salt precipitated out is then removed by suction and washed with a little diethyl ether.

Workup

  1. temperaturewith cooling
  2. customThe diazonium salt precipitated out
  3. customis then removed by suction
  4. washwashed with a little diethyl ether

Sources & evidence

ORD record
ord-9a2a7d0e1ae9476bbf2ca0cecb42574d
Source dataset
uspto-grants-1996_05
Patent number
US05516932

Reaction notes

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