反应详情

A mixture of decafluorobiphenyl (1.67 g, 5 mmol), propargyl alcohol (0.58 ml), potassium carbonate (7.5 g), and 18-crown-6 (0.1 g) in 30 ml of toluene was stirred under reflux for 8 hours. After cooling to room temperature, 2 g of celite was added and the reaction mixture was filtered. The filtrate was evaporated on a rotavapor to remove most of the solvent and then the product was purified by preparative gas chromatography, giving 0.93 g (48%) of 4-propargyloxynonafluorobiphenyl which was used in the next step.

1. temperatureunder reflux for 8 hours
2. addition2 g of celite was added
3. filtrationthe reaction mixture was filtered
4. customThe filtrate was evaporated on a rotavapor
5. customto remove most of the solvent
6. customthe product was purified by preparative gas chromatography