HRID440231

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15908

1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide

C8H17N3

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

HCID78288

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-

C7H13NO4

结构：C[C@H](NC(=O)CNC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1

HCID14656486

未命名化合物

2 次

HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

PRODUCTS

生成物

结构：C[C@H](NC(=O)CNC(=O)CNC(=O)OC(C)(C)C)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1

HCID131719402

未命名化合物

收率 85.9%

PROCEDURE

实验过程

Compound II (65.03 g, 0.15 mole) was deblocked with HCl/dioxane and coupled to Boc-Gly-OH (26.3 g, 0.15 mole) using EDCI with HOBt in the same manner as that described for II to give 63.2 g (yield 85.9%) of III Rf1, 0.3; Rf2, 0.46.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bba9ca61a2634869bafebecd68ef9fdd
来源数据集: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05519004
来源说明: uspto-grants-1996_05

反应 SMILES

[NH:1]([C:25]([O:27]C(C)(C)C)=O)[CH2:2][C:3]([NH:5][C@H:6]([C:8]([N:10]1[CH2:24][CH2:23][CH2:22][C@H:11]1[C:12]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:13])=[O:9])[CH3:7])=[O:4].Cl.O1CCOCC1.[NH:39]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:40]C(O)=O.CCN=C=NCCCN(C)C.C1C=CC2N(O)N=NC=2C=1>>[NH:39]([C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[CH2:40][C:25]([NH:1][CH2:2][C:3]([NH:5][C@H:6]([C:8]([N:10]1[CH2:24][CH2:23][CH2:22][C@H:11]1[C:12]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:13])=[O:9])[CH3:7])=[O:4])=[O:27]