反应详情

Cool methyl phenylacetate (1.80 mL, 12.5 mmol) to 0° C. using and ice/water bath. Add dropwise and with vigorous stirring, a solution of trimethylsilyl triflate (2.70 mL, 4 mmol) and triethylamine (1.95 mL, 14 mmol) in dry ether (25 mL). When the addition is complete, warm slowly to ambient temperature. After 4.5 hours, cool in an ice/bath to obtain a heavier reddish oil. Remove the reddish oil by syringe. Evaporate the ether under high vacuum at 0° C. to obtain a residue and dissolve the residue in dichloromethane (25 mL) to give the title compound as a solution in dichloromethane which is used without further purification.

1. additionAdd dropwise and with vigorous stirring
2. additionWhen the addition
3. temperaturecool in an ice/bath
4. customto obtain a heavier reddish oil
5. customRemove the reddish oil by syringe
6. customEvaporate the ether under high vacuum at 0° C.
7. customto obtain a residue