Hydrochloric Acid → HCID 67742446, compound

HRID 440567Notes

Reaction equation

HRID 440567 reaction equation
[OH-].[Na+].[CH:3]([C:6]1([C:12]([O:14][CH3:15])=[O:13])[CH2:10][CH2:9][CH2:8][C:7]1=[O:11])([CH3:5])[CH3:4].[Cl:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=1.Cl>O.CO>[Cl:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[C:8]2[CH2:9][CH2:10][C:6]([CH:3]([CH3:5])[CH3:4])([C:12]([O:14][CH3:15])=[O:13])[C:7]2=[O:11])=[CH:19][CH:18]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 77264-ChlorobenzaldehydeHCID 14798Sodium HydroxideHCID 12586402Methyl 2-oxo-1-(propan-2-yl)cyclopentane-1-carboxylate

Product 1

HCID 67742446HCID 67742446, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a solution of 4 g of sodium hydroxide in 1000 ml of water were added 21 g of methyl 1-isopropyl-2-oxocylopentanecarboxylate (prepared in Reference Example 2 hereinafter) and a solution of 16 g of 4-chlorobenzaldehyde in 1000 ml of methanol, and the mixture was stirred for 5 hours at room temperature. The reaction mixture was neutralized with diluted hydrochloric acid and the precipitate was collected by filtration. Product 33.6 g (yield, 96.2%)

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-abfcdc5f83c94e85a5d242a9e64597fd
Source dataset
uspto-grants-1996_05
Patent number
US05519160

Reaction notes

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