反应详情

A mixture of 20.0 g (0.088 mole) of 3-chloro-2-(2-methyl-2-propen-1-yl)-6-nitrophenol and 0.35 g (0.002 mole) of p-toluenesulfonic acid in 100 mL of xylene was heated at reflux for approximately 16 hours. The solvent was evaporated under reduced pressure, leaving a residue which was passed through a column of silica gel, eluting with methylene chloride. The product-containing fractions were combined, washed with an aqueous solution of sodium hydroxide, dried over anhydrous magnesium sulfate, and the solvent evaporated under reduced pressure, yielding 16.85 g of 4-chloro-2,3-dihydro-2,2-dimethyl-7-nitrobenzofuran as an oil.

1. temperaturewas heated
2. temperatureat reflux for approximately 16 hours
3. customThe solvent was evaporated under reduced pressure
4. customleaving a residue which
5. washeluting with methylene chloride
6. washwashed with an aqueous solution of sodium hydroxide
7. dry with materialdried over anhydrous magnesium sulfate
8. customthe solvent evaporated under reduced pressure