反应详情

A mixture of 4-bromoacetyl-5-methyl-2-phenyloxazole (7.0 g), p-cyanophenol (3.0 g), potassium carbonate (6.9 g) and methyl ethyl ketone (100 ml) was heated under reflux for 2 hours. The reaction mixture was concentrated under reduced pressure, and water (100 ml)-ether (100 ml) was added to the residue. The mixture was stirred, and the crystals were collected by filtration. Recrystallization from chloroform-ethanol afforded 4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile (6.3 g, 78.8%), as brownish prisms, m.p. 202°-203° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. concentrationThe reaction mixture was concentrated under reduced pressure, and water (100 ml)-ether (100 ml)
4. additionwas added to the residue
5. filtrationthe crystals were collected by filtration
6. customRecrystallization from chloroform-ethanol