反应详情

To a solution of 2-(1-pyrrolyl)benzoic acid (206 mg), diphenyl chlorophosphate (325 mg), 1-(4-aminobenzoyl}-1,2,3,4-tetrahydroquinoline (277 mg) in tetrahydrofuran (10 ml) was added triethylamine (333 mg) at 0° C. The resulting mixture was allowed to warm to ambient temperature where it was maintained for 5 hours. The solvent was evaporated and diluted with ethyl acetate and washed with water, saturated sodium bicarbonate aqueous solution and brine. The organic layer was dried over sodium sulfate and concentrated to give 1-{4-[2-(1-pyrrolyl)benzoylamino]benzoyl}-1,2,3,4tetrahydroquinoline (280 mg).

1. temperaturewas maintained for 5 hours
2. customThe solvent was evaporated
3. additiondiluted with ethyl acetate
4. washwashed with water, saturated sodium bicarbonate aqueous solution and brine
5. dry with materialThe organic layer was dried over sodium sulfate
6. concentrationconcentrated