反应详情

26 ml of methyl isocyanate were added to a mixture of 11.6 g of triethylamine and 22.3 g of m-amino-3-methoxy-crotonanilide in 250 ml of tetrahydrofuran and the mixture was stirred for 16 hours and vacuum filtered. The recovered precipitate was washed with isopropyl ether to obtain 23 g of m-(N-methyl-ureido)-3-methoxy-crotonanilide melting at 166° C. Crystallization from ethanol did not change the melting point.

1. filtrationvacuum filtered
2. washThe recovered precipitate was washed with isopropyl ether