Acetone → HCID 178444021, compound

HRID 441334Notes

Reaction equation

HRID 441334 reaction equation
[Na].CC(C)=O.Cl.[C:7]([NH2:15])(=[NH:14])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].[F:16][C:17]1[CH:22]=[CH:21][C:20]([N:23]=[C:24]=[S:25])=[CH:19][CH:18]=1>C1C=CC=CC=1.CCCCC>[F:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24]([NH:14][C:7](=[NH:15])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[S:25])=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 180Acetone2×HCID 152414-Fluorophenyl isothiocyanateHCID 5360545SodiumHCID 14144282Heptanimidamide hydrochloride

Product 1

HCID 178444021HCID 178444021, compound

Reagents, catalysts & solvents 1

HCID 19707280Benzene n-pentaneSolvent

Procedure

Following a procedure similar to that described in Example 1 but using 1.6 g. sodium in 200 ml. dry acetone, 12.3 g. heptanamidine hydrochloride, and 11.6 g. 4-fluorophenyl isothiocyanate (b.p. 48° C./0.025 mm.; prepared from 4-fluoroaniline) in 50 ml. dry acetone there was obtained 1-(4-fluorophenyl)-3-(heptanimidoyl)-2-thiourea, m.p. 75°-76° C. (from benzene-n-pentane); hydrochloride (17.1 g.), m.p. 155° C. (from acetonitrile).

Sources & evidence

ORD record
ord-6e9b11edbfdb4f979c7d36588f5c941a
Source dataset
uspto-grants-1977_08
Patent number
US04039575

Reaction notes

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