4-Chlorophenyl isothiocyanate → HCID 178444017, compound

HRID 441338Notes

Reaction equation

HRID 441338 reaction equation
[Na].Cl.[CH3:3][C:4]([CH3:11])([CH3:10])[CH2:5][CH2:6][C:7]([NH2:9])=[NH:8].[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[S:21])=[CH:15][CH:14]=1>CC(C)=O>[Cl:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:8][C:7](=[NH:9])[CH2:6][CH2:5][C:4]([CH3:11])([CH3:10])[CH3:3])=[S:21])=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 164804-Chlorophenyl isothiocyanateHCID 5360545SodiumHCID 21420653HCID 21420653, compound

Product 1

HCID 178444017HCID 178444017, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

Following a procedure similar to that described in Example 1 but using 7.22 g. sodium in 705 ml. dry acetone, 51.7 g. 4,4-dimethylvaleramidine hydrochloride, and 53.2 g. 4-chlorophenyl isothiocyanate in 350 ml. dry acetone there was obtained 1-(4-chlorophenyl)-3-(4,4-dimethylpentanimidoyl)-2-thiourea; m.p. 135°-137° C. (from acetonitrile); hydrochloride (80.7 g.), m.p. 182°-186° C.

Sources & evidence

ORD record
ord-107378326ba14e7189f71981dbb70d79
Source dataset
uspto-grants-1977_08
Patent number
US04039575

Reaction notes

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